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雷公藤多苷联合糖皮质激素治疗儿童紫癜性肾炎的临床疗效观察

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龙源期刊网 http://www.qikan.com.cn 雷公藤多苷联合糖皮质激素治疗儿童紫癜性 肾炎的临床疗效观察 作者:向明 来源:《上海医药》2014 年第 17 期 (江西省九江市妇幼保健院 九江 332000) 摘 要 目的:探讨雷公藤多苷联合糖皮质激素治疗儿童紫癜性肾炎的临床疗效。方法:选 取 2009 年 1 月-2011 年 7 月在我院就诊并确诊为紫癜性肾炎(急性肾炎型)的患儿 42 例,随 机分为治疗组和对照组各 21 例。对照组采用泼尼松、双嘧达莫、维生素 C、抗过敏药物、钙 剂等常规治疗;治疗组在对照组基础上加用雷公藤多苷治疗。观察分析两组患儿的临床疗效及 不良反应。结果:治疗组患者的治疗总有效率为 90.5%,明显高于对照组(71.2%);治疗组 患儿血尿、蛋白尿、高血压及水肿等临床症状的消失时间均短于对照组,且复发率明显低于对 照组,差异都有统计学意义。结论:小剂量雷公藤多苷联合糖皮质激素治疗儿童紫癜性肾炎临 床疗效显著,复发率低,无明显毒副作用,值得临床应用。 关键词 雷公藤多苷 糖皮质激素 紫癜性肾炎 中图分类号:R726.9; R286 文献标识码:B 文章编号:1006-1533(2014)17-0025-03 Observation on the clinical efficacy of tripterygium glycosides combined with glucocorticoid in the treatment of child henoch-schonlein purpura nephritis* XIANG Ming** (Maternal and Child Health Care of Jiujiang City, Jiangxi province, Jiujiang 332000, China) ABSTRACT Objective: To discuss the clinical efficacy of tripterygium glycosides combined with glucocorticoid in the treatment of child henoch-schonlein purpura nephritis (HSPN). Methods: Forty-two cases of child HSPN (acute nephritis type) patients treated in our hospital from January 2009 to July 2011 were divided into a treatment group and a control group with 21 cases each by randomized method. Conventional therapy including prednisone, dipyridamole, vitamin C, anti-allergic drugs and calcium was given in two groups, and in addition, tripterygium glycosides was given in the treatment group. The clinical efficacy and adverse reaction in both groups were observed and analyzed. Results: The total treatment efficiency in the treatment group was 90.5%, which is higher than that in the control group (71.2%). The disappear time of all clinical symptoms such as haematuria, proteinuria, hypertension and edema was shorter in the treatment group than in the control group as well as the recurrence rate. All the differences were statistically 龙源期刊网 http://www.qikan.com.cn significant. Conclusion: Small dose of tripterygium glycosides combined with glucocorticoid in the treatment of child henoch-schonlein purpura nephritis has significant clinical efficacy with low recurrence rate and no significant adverse reaction, which is worthy of clinical use. KEY WORDS tripterygium glycosides; glucocorticoid; henoch-schonlein purpura nephritis 紫癜性肾炎(henoch-schonlein purpura nephritis,HSPN)是儿科最常见的肾炎病,继发于 过敏性紫癜。HSPN 通常在过敏性紫癜发病 1 周~3 个月内出现肾脏损害的临床表现,极少数 在过敏性紫癜之前就有所表现。*几年来 HSPN 患病率逐年升高,虽大多患者经治疗后预后较 好,但仍有 15%患者伴有持续性肾病,且 1.0%~15.7%患者发展到终末期肾病[1]。为探讨儿 童紫癜性肾炎的有效治疗方案,本研究选取 2009 年 1 月-2011 年 7 月在我院就诊的 HSPN(


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